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Author Dr Amanda Oakley, Dermatologist, Hamilton New Zealand, in 1. Updated in January 2. Acknowledgement Many images have been supplied by Mole. Map NZ. What is a mole A mole is a common benign skin lesion due to a local proliferation of pigment cells melanocytes. It is more correctly called a melanocytic naevus American spelling nevus, and is sometimes also called a naevocytic naevus. A brown or black mole contains the pigmentmelanin, so may also be called a pigmented naevus. A mole can be present at birth congenital naevus or appear later acquired naevus. There are various kinds of congenital and acquired naevi American spelling nevi. Who gets moles Almost everyone has at least one mole. U1MDcE41aTLrDsk-GwKXG8bn3KIavETPhffMFmNVulQqqPyczI63z1oxHcR3Gxkncw9w=h310' alt='Abcd Same Game' title='Abcd Same Game' />Why are Wireless Buzzers increasing in popularity With our Game Show Buzzers you can make money with trivia, wireless buzzers and customizable trivia software. About 1 of individuals are born with one or more congenital melanocytic naevi. This is usually sporadic, with rare instances of familial congenital naevi. Fair skinned people tend to have more moles than darker skinned people. Moles that appear during childhood aged 2 to 1. Moles that are acquired later in childhood or adult life often follow sun exposure. Most white skinned New Zealanders have 2. What causes moles Although the exact reason for local proliferation of naevus cells is unknown, it is clear that the number of moles a person has depends on genetic factors, on sun exposure, and on immune status. People with many moles tend to have family members that also have many moles, and their moles may have a similar appearance. Somatic mutations in RAS genes are associated with congenital melanocytic naevi. New melanocytic naevi may erupt following the use of BRAF inhibitor drugs vemurafenib, dabrafenib. People living in Australia and New Zealand have many more naevi than their relatives residing in Northern Europe. Immunosuppressive treatment leads to an increase in numbers of naevi. What are the clinical features of molesMoles vary widely in clinical, dermatoscopic and histological appearance. They may arise on any part of the body. Moles differ in appearance depending on the body site of origin. They may be flat or protruding. They vary in colour from pink or flesh tones to dark brown, steel blue, or black. Light skinned individuals tend to have light coloured moles and dark skinned individuals tend to have dark brown or black moles. Play Marble Games. Although mostly round or oval in shape, moles are sometimes unusual shapes. They range in size from a couple of millimetres to several centimetres in diameter. Classification of melanocytic naevi. Congenital melanocytic naevus. Congenital melanocytic naevi are classified according to their actual or predicted adult size in maximum dimension, and on specific characteristics. The pathological classification of melanocytic naevi relates to where naevus cells are found in the skin. Sketchup Pro 2013 Crack Serial. See more images of moles. Dermatoscopy has given rise to a new classification based on the pigment patterns of melanocytic naevi. Examples include Acquired melanocytic naevus. Ordinary moles that appear after birth may be referred to as acquired naevi. Acquired melanocytic naevi are given a variety of names and there is considerable overlap of descriptions. Signature naevi are the predominant group of naevi in an individual with multiple moles. Uncommon types of melanocytic naevi include Spitz naevus or epithelioid cell naevus a pink classic Spitz or brown pigmented Spitz dome shaped mole that arises in children and young adults. Reed naevus darkly pigmented type of Spitz naevus with starburst dermatoscopic pattern. Agminated naevi a cluster of similar moles. Kissing naevus adjacent melanocytic naevi on upper and lower eyelids, due to naevus formation prior to separation of eyelids in utero. The term atypical naevus may be used in several ways. A benign mole that has some clinical or histopathological characteristics of melanoma. A mole with specific characteristics large 5 mm ill defined or irregular borders varying shades of colour with flat and bumpy components. Or, any funny looking mole large, or different from the patients other moles. Atypical naevi usually occur in fair skinned individuals and are due to sun exposure. They may be solitary or numerous. Pathology is reported as dysplastic junctional or compound naevus and has specific histological features the Clark naevus. See more images of halo naevi. See more images of atypical naevi. What are the complications of moles People worry about moles because they have heard about melanoma, a malignant proliferation of melanocytes that is the most common reason for death from skin cancer. At first, melanoma may look similar to a harmless mole, but in time it becomes more disordered in structure and tends to enlarge. People with a greater number of moles have a higher risk of developing melanoma than those with few moles, especially if they have over 1. Moles sometimes change for other reasons than melanoma, for example following sun exposure or during pregnancy. They can enlarge, regress or involute disappear. A Meyerson naevus is itchy and dry because it is surrounded by eczema. A Sutton or halo naevus is surrounded by a white patch, and fades away over several years. A recurrent naevus is one that appears in a scar following surgical removal of a mole this may have an odd shape. How is a mole diagnosed Moles are usually diagnosed clinically by their typical appearance. If there is any doubt about the diagnosis, an expert may be consulted in person or with the help of clinical and dermatoscopic images. This is especially important if A mole changes size, shape, structure or colour. A new mole develops in adult life 4. It appears different from the persons other moles a so called ugly ducklingIt has ABCD characteristics Asymmetry, Border irregularity, Colour variation, Diameter 6 mmIt is bleeding, crusted or itchy. Most skin lesions with these characteristics are actually harmless when evaluated by an expert using dermatoscopy. Short term digital dermatoscopic imaging may be used in equivocal flat lesions to check for change over time. Naevi that remain suspicious for melanoma are excised for histopathology diagnostic biopsy. Partial biopsy is not recommended, as it may miss an area of cancerous change. What is the treatment for moles Most moles are harmless and can be safely left alone. Moles may be removed in the following circumstances To exclude cancer. The mole is a nuisance perhaps irritated by clothing, comb or razor. Cosmetic reasons the mole is unsightly. Surgical techniques include Can moles be prevented The number of moles can be minimised by strict protection from the sun, starting from birth. Sunscreen alone is not sufficient to prevent new moles from appearing. At any age, sun protection is important to reduce skin ageing and the risk of skin cancer. In New Zealand, the Sun. Smart Sun Protection Alert advises when protection is required. Cover up. Wear a hat, long sleeves and long skirt or trousers. Choose fabrics designed for the sun UPF 4. Apply sunscreen to areas you cant cover. Choose broad spectrum high protection SPF 5. What is the outlook for moles Most moles that appear in childhood remain forever. Teenagers and young adults tend to have the greatest number of moles. There are fewer in later life because some of them slowly fade away. To increase the chance of spotting melanoma early, recommend Self skin examination monthly. Significant changes in moles or new lesions are reported to doctor or dermatologist.



